The Commentary on Daniel was dedicated to Pammachius and Marcella in the year 407. It is in a single book, and is aimed at the criticisms of Porphyry, who, like most modern critics, took the predictions in the Book of Daniel as relating to the time of Antiochus Epiphanes and the Maccabees, and written near that date. The Preface is very similar to that prefixed to the Vulgate translation of Daniel.

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