SEV Biblia, Chapter 16:4
Y el tercer ngel derram su copa en los ríos, y en las fuentes de las aguas, y fueron vueltas en sangre.
Clarke's Bible Commentary - Revelation 16:4
Verse 4. Upon the rivers and fountains of waters] This is an allusion to the first Egyptian plague, Exod. vii. 20; and to those plagues in general there are allusions throughout this chapter. It is a sentiment of the rabbins that "whatever plagues God inflicted on the Egyptians in former times, he will inflict on the enemies of his people in all later times." See a long quotation on this subject from Rabbi Tanchum in Schoettgen.
John Gill's Bible Commentary
Ver. 4. And the third angel poured his vial upon the rivers and fountains of waters , etc.] Which also is not to be literally understood of a stagnation of them, before the burning of the world; nor of the destruction of Popish fleets and navies, such as the Spanish armada in 1588, and others since; but rather of Popish writings, of the most learned and subtle men among them, who like rivers and fountains, which supply and fill the sea, support and keep up the Romish jurisdiction and hierarchy; and of the confutation of them by Protestant writers; and of the utter destruction of their principal orders, and chief men among them, as cardinals, archbishops, bishops, priests, Jesuits, etc. though it seems chiefly to design the places near to Rome, such as Italy and Savoy; for as the third trumpet affects the rivers and fountains, ( Revelation 8:10) and brings in the Huns into Italy, and issued in the destruction of the empire; so the third vial affects the same, and brings terrible wars, and great effusion of blood, where so much of the blood of the saints have been shed: hence it follows, and they became blood; these countries will be covered with blood, and a reformation will ensue upon it; the allusion is to ( Exodus 7:19-21).
Matthew Henry Commentary
Verses 1-7 - We are to pray that the will of God may be done on earth as it is don in heaven. Here is a succession of terrible judgments of Providence and there seems to be an allusion to several of the plagues of Egypt The sins were alike, and so were the punishments. The vials refer to the seven trumpets, which represented the rise of antichrist; and the fall of the enemies of the church shall bear some resemblance to their rise. All things throughout their earth, their air, their sea, their rivers, their cities, all are condemned to ruin, all accursed for the wickedness of that people. No wonder that angels, who witness of execute the Divine vengeance on the obstinate haters of God, of Christ and of holiness, praise his justice and truth; and adore his awfu judgments, when he brings upon cruel persecutors the tortures they mad his saints and prophets suffer.
Greek Textus Receptus
και 2532 ο 3588 τριτος 5154 αγγελος 32 εξεχεεν 1632 5656 την 3588 φιαλην 5357 αυτου 846 εις 1519 τους 3588 ποταμους 4215 και 2532 εις 1519 τας 3588 πηγας 4077 των 3588 υδατων 5204 και 2532 εγενετο 1096 5633 αιμα 129
Vincent's NT Word Studies
4. The third angel. Omit angel.
They became (egeneto). There is no necessity for rendering the singular verb in the plural. We may say either it became or there came.